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Psychological interventions for relapse preventions in people with schizoprenia: Systematic review and network meta-analysis

The project was funded by the Federal Ministry of Education and Research (BMBF) (FKZ 01KG1803).

The project investigates the effect and acceptance of psychological interventions in the relapse prevention of schizophrenia.

Psychological interventions such as psychoeducation, family therapy and cognitive behavioural therapy are offered together with pharmacological treatments for the maintenance treatment in schizophrenia. However, it has not yet been studied which of these treatments is best for preventing relapse.

The method of network meta-analysis allows to estimate effect sizes for all possible comparisons of different psychological interventions, whether or not they were directly compared in a trial, allowing a comprehensive review of all available evidence.

The protocol of the study was registered a-priori in Prospero under the number CRD42017067795 (see here), and published in BMJ Open:

Bighelli I, Rodolico A, Pitschel-Walz G, Hansen WP, Barbui C, Furukawa TA, Salanti G, Leucht S. Psychosocial treatments for relapse prevention in schizophrenia: study protocol for a systematic review and network meta-analysis of randomised evidence. BMJ Open. 2020 Jan 19; 10(1):e035073. doi: 10.1136/bmjopen-2019-035073 (Link)

The results of the project were published in the Lancet:

Bighelli I, Rodolico A, García-Mieres H, Pitschel-Walz G, Hansen WP, Schneider-Thoma J, Siafis S, Wu H, Wang D, Salanti G, Furukawa TA, Barbui C, Leucht S. Psychosocial and psychological interventions for relapse prevention in schizophrenia: a systematic review and network meta-analysis. Lancet Psychiatry 2021; published online Oct 12. (Link)

Representatives of the association „BASTA - das Bündnis für psychisch erkrankte Menschen“ participated to the project, and together we prepared this summary of the project understandable for non-experts. (LINK)

The project was primarily conducted by Dr. Irene Bighelli, contact: irene.bighelli@tum.de

Supervisor: Professor Stefan Leucht